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Synonyms :
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Vascular Endothelial Growth Factor121, VPF
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Description :
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VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms -like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant human VEGF121 is a 28.4 kDa disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.
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Catalog #:
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100-20A
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Biological Activity :
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Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2-0.4 ng/ml.
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Selected References :
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Selected List of References Citing This Product
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AA Sequence :
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PMAEGGGQNH HEVVKFMDVY QRSYCHPIET LVDIFQEYPD EIEYIFKPSC VPLMRCGGCC NDEGLECVPT EESNITMQIM RIKPHQGQHI GEMSFLQHNK CECRPKKDRA RQENCDKPRR
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PubMed Link :
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VEGF+AND+121
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Country of Origin :
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USA
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Size A
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2µg
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$80
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Size B
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10µg
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$195
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Size C
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1mg
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$3900
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Special Sizes:
Many products can be ordered in custom sizes. Please click here to contact with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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