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Synonyms :
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GDF-8
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Description :
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Myostatin is a TGF-beta family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of myostatin activity facilitates muscle formation and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the Activin-binding protein Follistatin, and by the propeptide of Myostatin. Recombinant Human myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.
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Catalog #:
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120-00
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Biological Activity :
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Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED 50 for this effect is 17.0-25.0 ng/ml.
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Selected References :
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Selected List of References Citing This Product
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AA Sequence :
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DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS
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PubMed Link :
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Myostatin+OR+GDF-8
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Country of Origin :
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USA
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Size A
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2µg
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$80
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Size B
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10µg
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$195
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Size C
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1mg
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$5200
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Special Sizes:
Many products can be ordered in custom sizes. Please click here to contact with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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