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Synonyms :
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Twisted Gastrulation Protein
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Description :
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Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Recombinant human TSG is a 199 amino acid 22.2 kDa protein containing the BMP/TGFβ binding portion of the full length TSG protein.
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Catalog #:
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120-09
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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Biological Activity :
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Determined by its ability to neutralize BMP-6 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED 50 for this effect is < 2.0 μg/ml of TSG.
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Selected References :
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Selected List of References Citing This Product
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AA Sequence :
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MCNKALCASD VSKCLIQELC QCRPGEGNCS CCKECMLCLG ALWDECCDCV GMCNPRNYSD TPPTSKSTVE ELHEPIPSLF RALTEGDTQL NWNIVSFPVA EELSHHENLV SFLETVNQPH HQNVSVPSNN VHAPYSSDKE HMCTVVYFDD CMSIHQCKIS CESMGASKYR WFHNACCECI GPECIDYGSK TVKCMNCMF
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PubMed Link :
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Human+AND+TSG
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Country of Origin :
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USA
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Size A
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10µg
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$80
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Size B
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50µg
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$195
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Size C
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1mg
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$1500
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Special Sizes:
Many products can be ordered in custom sizes. Please click here to contact with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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